Science Fair Project Encyclopedia
Protease inhibitor (pharmacology)
- For natural protease inhibitors, please see protease inhibitor (biology)
Protease inhibitors are a class of medication used in viral infections. They act by inhibiting specific viral enzymes that are essential to the viral life cycle by cleaving viral proteins.
There are various viruses for which protease inhibitors have been developed (or are presently undergoing testing):
- HIV/AIDS: antiretroviral protease inhibitors (saquinavir , ritonavir , indinavir , nelfinavir etc.)
- Hepatitis C: experimental agents: BILN 2061, VX 950.
Given the specificity of the target of these drugs there is the risk, as in antibiotics, of the development of drug-resistant mutated viruses. To reduce this risk it is common to use together different drugs aimed at different targets.
Last updated: 05-28-2005 13:36:16
10-26-2009 08:16:03
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details