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It is inhibited when either of the three following ratios are increased: [ATP]/[ADP], [NADH]/[NAD+] and [acetyl-CoA]/[CoASH].
Pyruvate dehydrogenase is actually a big complex composed of 60 subunits: 24 pyruvate dehydrogenase (E1), 24 dihydrolipoyl transacetylase (E2) and 12 dihydrolipoyl dehydrogenase (E3).
The global reaction catalysed by pyruvate dehydrogenase is:
- pyruvate + CoA + NAD+ ⇒ acetyl-CoA + NADH + H+ + CO2
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