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Quinolone
(Redirected from Quinolones)
Quinolones and fluoroquinolones form a group of broad-spectrum antibiotics. They are derived from nalidixic acid.
Fluoroquinolone antibiotics are highly potent and considered relatively safe. However, they can have potentially troublesome side effects. For example, case reports have implicated their use in rare instances of tendon damage, especially when administered with a systemic corticosteroid.
Mechanism
Quinolones act by inhibiting the bacterial DNA gyrase enzyme. This way they inhibit nucleic acid synthesis and act bacteriocidically.
Examples
- Ciprofloxacin (Cipro®)
- Levofloxacin (Levaquin®)
- Norfloxacin (Noroxin®)
- Ofloxacin
- Moxifloxacin (Avelox®)
- Gemifloxicin (Factive®)
External links
10-26-2009 08:16:03
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details