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SH3 domain
An SH3 domain is a protein module , a characteristic peptide sequence. It is used in signal transduction proteins, often in pathways involving tyrosine kinases. SH3 domains bind to proline-rich sequences (or polyproline helices). SH stands for src homology.
SH3 domains have a consensus sequence:
-X-P-p-X-P- 1 2 3 4 5
with 1 and 4 being aliphatic amino acids, 2 and 5 always and 3 sometimes being proline. The sequence binds to the hydrophobic pocket of the SH3 domain.
SH3 domains are often found in functions concerning the cytoskeleton, the ras protein, and the src kinase . They also increase the substrate specificity of tyrosine kinases by binding far away from the catalytic center of the kinase.
See also: Src homology 2 domain-containing
03-10-2013 05:06:04
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details