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An SH3 domain is a protein module , a characteristic peptide sequence. It is used in signal transduction proteins, often in pathways involving tyrosine kinases. SH3 domains bind to proline-rich sequences (or polyproline helices). SH stands for src homology.
SH3 domains have a consensus sequence:
-X-P-p-X-P- 1 2 3 4 5
SH3 domains are often found in functions concerning the cytoskeleton, the ras protein, and the src kinase . They also increase the substrate specificity of tyrosine kinases by binding far away from the catalytic center of the kinase.
See also: Src homology 2 domain-containing
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