Salusa Secundus is a fictional planet appearing in Frank Herbert's Dune universe. It is the third planet of the Gamma Waiping system and home to the Imperial House, House Corrino.

House Corrino was driven from the lush planet of Salusa Secundus long before the setting of the novel Dune by an atomic attack carried out by a rival House. This House was subsequently exterminated and no record of its name exists by the time of the novel. The Corrinos relocated the Imperial capital to Kaitain and Salusa was left as a barren wasteland. It was publically believed that Salusa was the emperor's prison planet. However, it eventually emerged that House Corrino also made use of the planet as a training ground for the Sardaukar troops.

After the fall of the Imperium to Paul Atreides, House Corrino was exiled to Salusa Secundus with the exception of Princess Irulan. In the novel Children of Dune, Princess Wensicia, the daughter of Shaddam IV, plotted an attempt to retake control of the empire for her son, Farad'n.