Santa Maria may refer to:

Holy Mary

• The name of the Blessed Virgin Mary or Mary, the mother of Jesus, in various languages such as Italian, Portuguese, Spanish and Catalan

Columbus' ship

• Santa Maria, the largest of the three ships used by Christopher Columbus in his first voyage across the Atlantic Ocean

Place names

• Santa Maria, an island in the Azores
• Santa Maria, a volcano in Guatemala

In the United States

• Santa Maria, a city in the state of California
• Santa Maria, a city in the state of Texas

In Brazil

• Santa Maria, a city in the state of Rio Grande do Sul
• Santa Maria das Barreiras , a city in the state of Pará
• Santa Maria da Boa Vista , a city in the state of Pernambuco
• Santa Maria do Cambucá , a city in the state of Pernambuco
• Santa Maria do Herval , a city in the state of Rio Grande do Sul
• Santa Maria de Itabira , a city in the state of Minas Gerais
• Santa Maria de Jetibá, a city in the state of Espírito Santo
• Santa Maria Madalena , a city in the state of Rio de Janeiro
• Santa Maria do Oeste , a city in the state of Paraná
• Santa Maria do Pará , a city in the state of Pará
• Santa Maria do Salto , a city in the state of Minas Gerais
• Santa Maria da Serra, a city in the state of São Paulo
• Santa Maria do Suaçuí , a city in the state of Minas Gerais
• Santa Maria do Tocantins , a city in the state of Tocantins
• Santa Maria da Vitória , a city in the state of Bahia

In Italy

• Santa Maria , a town on the island of Ponza
• Santa Maria , a neighborhood of Schio
• Santa Maria Zobenigo or Santa Maria del Giglio, a church in Venice

In Portugal

• Santa Maria, a parish in the district of Bragança
• Santa Maria , a parish in the district of Celorico da Beira
• Santa Maria , a parish in the district of Covilhã
• Santa Maria , a parish in the district of Estremoz
• Santa Maria , a parish in the district of Lagos
• Santa Maria , a parish in the district of Manteigas
• Santa Maria , a parish in the district of Óbidos
• Santa Maria , a parish in the district of Odemira
• Santa Maria , a parish in the district of Serpa
• Santa Maria , a parish in the district of Tavira
• Santa Maria , a parish in the district of Torres Novas
• Santa Maria , a parish in the district of Trancoso