Seal of the Prophets is a title given to Muhammad by a verse in the Qur'an (33:40). This verse is interpreted in Islamic Tradition as meaning that Muhammad was the last of the prophets. He is not only considered a prophet, but also a messenger, since he was the medium through which the Qur'an was revealed.

Before Muhammad, the terms were reputedly used in Manichaeism, a Persian faith whose founder Mani claimed to be the Seal of the Prophets and The Last Prophet.

For the Christians, however, prophets may continue to appear after Jesus. For example, in the Book of Acts, the prophet Agabus appears (Acts 21:10). Also, prophets are mentioned in Acts 13 (13:1).

In recent history, the interpretation of the term “seal of the prophets” has been a cause of much contention between the Lahore Ahmadiyya Movement and the Ahmadiyya Muslim Community. The differences arose due to differences in the definition and usage of the terms “seal” and “prophet”.