Science Fair Project Encyclopedia
Quetiapine
Quetiapine (kwe-TYE-a-peen), marketed by AstraZeneca with the brand name Seroquel, is one of the atypical antipsychotics. Quetiapine has FDA and international approvals for the treatment of schizophrenia and acute mania in bipolar disorder. It is used "off-label" to treat other disorders, such as post-traumatic stress disorder, and as a sedative for those with sleep disorders.
| Contents |
Chemistry
Quetiapine (shown in figure) is 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine, C21H25N3O2S. Dosages are based on millgrams of this base. The Seroquel formulation is as a fumarate salt with the chemical formula C42H50N6O4S2·C4H4O4 and systematic name 2-[2-(4-dibenzo [b,f] [1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol fumarate (2:1) (salt).
How it works
Quetiapine is a dopamine, specifically D1 and D2 dopamine, inhibitor or antagonist. It also somewhat inhibits functioning of serotonin receptors, but in clinical tests it has been found that the human body is very adaptive to the serotonin blocking reaction, thus it can be used together with SSRI medication.
Side effects
Quetiapine is believed to be less likely to cause tardive dyskinesia than typical antipsychotics. However, as with other antipsychotics, there is evidence implying that quetiapine may cause tardive dyskinesia. [1] [2]
Studies conducted on beagles have resulted in the formation of cataracts, however, there has been no report describing this effect within humans. Common side effects include: agitation, memory problems, sedation, and an upset stomach. More information on side effects can be found at NIH's profile of the medication. Seroquel will put the patient into a drowsy state, and will help the patient fall asleep.
External links
- Seroquel brand website
- Seroquel is listed in many drug information databases, including the RxList (see http://www.rxlist.com/cgi/generic2/quetiap.htm) and the British National Formulary (BNF) (see http://www.bnf.org/bnf).
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details