Science Fair Project Encyclopedia
Sharpless epoxidation
Sharpless epoxidation is a chemical reaction of an allylic alcohol with t-butylperoxide and titanium tetraisopropylate to form an epoxide. To form chiral products it is possible to add diethyltartrates.
Epoxides can be easily converted into dialcohols, aminoalcohols or ethers, so formation of chiral epoxides is a very important step in the synthesis of natural products.
K. Barry Sharpless shared the Nobel prize in 2001 with William S. Knowles and Ryoji Noyori for his work on asymmetric oxidations.
03-10-2013 05:06:04
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details