Sisal is a seaport town in the state of Yucatán, Mexico. It was the principal port of Yucatán during the henequen boom, later overshadowed when the more modern port of Progreso was built to the east. It lent its name to the agave-derived sisal fiber which was shipped through it.

The town is about 53 km north north-west of Mérida, the state capital. By law when the Yucatán was part of New Spain, all commerce went through the port of Campeche. The residents of Mérida petititioned for a port closer to the capital, and this was granted by Spanish royal decree on 13 February 1810. The new port of Sisal was founded in 1811, and has a late colonial era fortress, the "Castle of Sisal", and an old lighthouse. After Yucatán's independence from Spain commerce in the port grew rapidly, and by 1845 was shipping cargos with twice the value that had previously gone through Campeche. After the development of Progreso, Sisal's importance declined and today is a small fishing village, visited by some for its beach.