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Sphingosine

Sphingosine is a compound that forms a primary part of sphingomyelin, an important phospholipid. Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2.


Synthesis

Sphingosine is synthesized from palmitoyl CoA and serine in a condensation requires to yield dehydrosphingosine. Dehydrosphingosine is then reduced by NADPH to dihydrosphingosine, and finally oxidized by FAD to sphingosine.

03-10-2013 05:06:04
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