I snipped:

Additionally vertebrate and mammalian systems show a high degree of differentiation between their immune systems compared to other bodily systems. This can present a problem when trying to extrapolate experimental results from animal models (often from mice to humans).

Can anyone source this? It's too strong a statement to go without a source. jdb ❋ 03:46, 7 Feb 2005 (UTC)

Most of this came from Goldsby. Though I think that piece might be one of the things I had gotten somewhere else.

What it was trying to convey that the physiology immune system of a mouse and a man shows more difference than say the digestive system. This means using animal models is particularly hard when dealing with immune systems.

This is basically expected when you think about the nature of the immune system. Even my immune system compared to your immune system is going to have a lot less compatibility compared to our digestive systems.--ZayZayEM 04:12, 8 Feb 2005 (UTC)

I daresay that while you and I probably differ greatly in our MHC genes and VDJ segments, and we while certainly differ in terms of our instantitated T and B cells, we probably differ very little in terms of the mechanics of the immune system. As to mice, I realize that there are inter-species differences, given how extensively mice are used in immunology research, I'm hesistant to include a paragraph like the one above without more detail, as it gives the wrong impression. jdb ❋ 05:44, 8 Feb 2005 (UTC)