Thomas de Cantilupe (c. 1218 - 25 August 1282), English saint and prelate, was a son of William de Cantilupe, the 2nd baron (d. 1251), one of King John's ministers, and a nephew of Walter de Cantilupe , bishop of Worcester.

He was educated at Paris and Orleans, afterwards becoming a teacher of canon law at Oxford and chancellor of the university in 1262. During the Barons' War Thomas favoured Simon de Montfort and the baronial party. He represented the barons before St Louis of France at Amiens in 1264; he was made chancellor of England in February 1265, but was deprived of this office after Montfort's death at Evesham, and lived out of England for some time. Returning to England, he was again chancellor of Oxford University, lectured on theology, and held several ecclesiastical appointments. In 1274 he attended the second council of Lyons, and in 1275 he was appointed bishop of Hereford.

Cantilupe was now a trusted adviser of Edward I; he attended the royal councils, and even when differing from the king did not forfeit his favour. The archbishop of Canterbury, Robert Kilwardby, was also his friend; but after Kilwardby's death in 1279 a series of disputes arose between the bishop and the new archbishop, John Peckham, and this was probably the cause which drove Cantilupe to visit Italy. He died at Orvieto, on the 25th of August 1282, and he was canonised in 1330.

Cantilupe appears to have been an exemplary bishop both in spiritual and secular affairs. His charities were large and his private life blameless; he was constantly visiting his diocese, correcting offenders and discharging other episcopal duties; and he compelled neighboring landholders to restore estates which rightly belonged to the see of Hereford. In 1905 the Cantilupe Society was founded to publish the episcopal registers of Hereford, of which Cantilupe's is the first in existence.

|- style="text-align: center;" | width="30%" |Preceded by:
John de Breton | width="40%" style="text-align: center;" |Bishop of Hereford
1275–1282 | width="30%" |Succeeded by:
Richard Swinfield