Tlatelolco is an area in Mexico City, centered around the Plaza de las Tres Culturas , a square surrounded on three sides by an excavated Aztec pyramid, the 17th century church Templo de Santiago , and the modern office complex of the Mexican foreign ministry.

During the Aztec rule, it was the market district of the Aztec capital Tenochtitlán, probably one of the largest in the Americas. According to Conquistador Bernal Díaz del Castillo, it was larger than any market any of the Spaniards had seen, even those of Venice and Constantinople.

When the conquistadors led by Hernán Cortés lay siege to Tenochtitlán, and conquered and razed it district by district, the Aztecs, led by Cuauhtemoc, were finally confined to Tlatelolco, where they made their last stand, and were defeated and slaughtered by the conquistadors. Over 40,000 Aztec men, women, and children perished at Tlatelolco on August 13, 1521.

In 1967, the Treaty of Tlatelolco was opened for signature, with the aim of establishing a nuclear weapons-free zone throughout Latin America and the Caribbean. Since then, all the region's countries have signed and ratified the treaty.

On October 2, 1968, the plaza was the scene of the Tlatelolco massacre, in which more than 300 student protestors were killed by army and police.

The Nonoalco-Tlatelolco housing project, built in the 1960s, is served by Metro Tlatelolco. It is also home to the pyramid-shaped Banobras building, which houses a 47-bell carillon. At 125 m, this is the world's tallest carillon tower.