Antonio (Tony) Lupusella (born June 12, 1944 in Cardinale , Italy) is a former politician in Ontario, Canada. He was a member of the Legislative Assembly of Ontario from 1975 to 1990. Originally a New Democrat, he later crossed the floor to the Liberal Party.

Before entering politics, Lupusella worked with Centro, an Italian organization which grew out of the Union of Injured Workers.

He was first elected to the Ontario legislature in the 1975 provincial election, defeating Progressive Conservative incumbent George Nixon by 1,465 votes in the north Toronto riding of Dovercourt . It may be noted that the NDP won several Italian ridings in north Toronto during this election. He was re-elected over Nixon by a greater margin in the 1977 election. In the 1981 provincial election, he was re-elected over Liberal Gil Gillespie by only 294 votes, as the Liberal Party increased its presence in the city.

Lupusella defeated Gillespie a second time, by only 77 votes in the 1985 provincial election. Following this election, the Liberals and NDP formed a two-year parliamentary alliance, and defeated the Progressive Conservative government in the legislature (the PCs had previously governed Ontario since 1943). Redistribution of electoral boundaries forced Lupusella to run against fellow NDP MPP Ross McClellan for the party's nomination in Dovercourt after McClellan's Bellwoods riding was wiped off the map. McClellan defeated Lupusella and, on December 17, 1986, Lupusella crossed the floor to join the Liberal caucus of Premier David Peterson as a backbencher.

In the 1987 provincial election Lupusella defeated McClellan by 907 votes.

The Liberals were unexpectedly defeated by the NDP in the 1990 provincial election, and Lupusella lost his seat to NDP candidate Tony Silipo. He has not sought a return to the legislature since this time.