Vitsa is one of the most considerable villages of Zagori, with an important history starting from the first steps of man. During the historic times Zagori was inhabited by the race of Molossos, as we can conclude from findings at the diggings in Vitsa, containing the remains of a neolithic settlement of Molossoi dated to the 9th until the 4th century B.C. The establishment of the village of Vitsa is referred to in other documents from 1321 to 1361. Some buildings from Byzantine times are still preserved.

After 1430, when the Turks conquered Ioannina, Vitsa and other Zagori villages formed a self-governed federation. The privileges which were granted to the federation of Zagori and which are dued, in the biggest part, to the influence of rich Zagorians over the court of the Sultan, were preserved until 1868. According to these privileges, Zagori was autonomous and self-governed under the surveillance of Vekili of Zagori . Another important privilege that the Zagorians had, was the freedom to practise their religious duties. Thanks to the intelligence and the political power of many Zagorian patriots who had administrative posts at lpsili Pili (turkish administration), these privileges were increased and improved. The autonomy, the self-government, and the fact that they were not being subjected helped the inhabitants to reach an enviable standard of living.

Vitsa (Vezitsa during the Byzantine times) became a cultural center for the Zagori region and was the birth place of many important people such as the Sarros family (politicians and engineers at the Suez canal) and Nikolaidis (man of literature).