The Western Region of Ghana includes the large cities of Sekondi and Takoradi on the coast, coastal Axim and a hilly inland area including Elubo , that reaches from the Côte d'Ivoire border in the west, to the Central Region (Ghana) in the east. It includes Ghana's southernmost location, Cape Three Points .

The region has the highest rainfall in Ghana, lush green hills and fertile soils. There are numerous small and large-scale gold mines. The culture is dominated by the Nzema branch of the Akan culture, and the main languages are Fante, Nzema and English. The religions are predominantly Christian and traditional fetish priest cults.

The founder of modern independent Ghana, Kwame Nkrumah was born (and later temporarily buried) in the village of Nkroful, west of Axim where he once taught school in the 1930's.

The largest rivers are the Ankobra River, the Pra River in the east and the Tana River partly forming the western national border. The area is known for the village of Nzulezo built entirely on stilts and platforms over water, and the Ankasa Protected Area . There is a series of imposing Portuguese, Dutch, British, and Brandenburgian forts along the coast, built from 1512 on.