William de la Pole is the name of several prominent Engishmen in the 14th century, all from the same family.

Sir William de la Pole (died about 1329) was a merchant in Kingston-upon-Hull and Ravenser Odd.

Sir William de la Pole (d. 1366) was a wealthy merchant in Kingston-upon-Hull and Ravenser Odd, a royal moneylender and baron of the Exchequer.

His family background is obscure. He was once thought to be the son of the earlier William de la Pole above, but this has been disproven.

Sir William was, along with his older brother Sir Richard de la Pole, a strong supporter of the government of Roger Mortimer and Queen Isabella. They loaned the pair large sums of money in 1327, and in return received appointment as gaugers of wine throughout England, and control of customs in Hull and later in London. They lost some of these posts after Mortimer's fall, but their wealth meant they could be totally excluded from the government of Edward III.

In 1332 Sir William convinced the king to convert the office of chief magistrate of Hull to Lord Mayor of Hull, a post which filled for the next 4 years. He also represented the city of Hull in five sessions of parliament (March 1332, September 1334, May 1336, September 1336, and February 1338).

During this time he continued as the king's financier, and in 1339 he was appointed second baron of the exchequer. The next year, however, Edward III had him arrested and imprisoned. He was convicted, though the charges were anulled by Parliament in 1344.

William de la Pole, 1st Duke of Suffolk (1396-1450) was his great-grandson.