Zygote Intrafallopian Transfer (ZIFT) is an infertility treatment in which egg cells are removed from a woman's ovaries, and fertilized in the laboratory. The resulting zygote is placed into the fallopian tube by the use of laparoscopy. The procedure is a spin-off of the GIFT (Gamete Intrafallopian Transferprocedure. Both GIFT and ZIFT are most effectively used to artificially fertilize a woman with temporary or permanent blockages in her fallopian tubes, because they allow placement of gametes or a zygote past the blockage.

It takes, on average, four to six weeks to complete a cycle of ZIFT. First, the woman must take a fertility medication to stimulate egg production in the ovaries. The doctor will monitor the growth of the ovarian follicles, and once they are mature, the woman will be injected with human chorionic gonadotropins (hCG). The eggs will be harvested approximately 36 hours later, usally by guidance of transvaginal ultrasound. After fertilization in the laboratory the resulting early embryos or zygotes are placed into the woman's fallopian tubes using a laparoscope. The need for two interventions and the fact that IVF results are equal or better (in 2004) leaves few if any indications for this intervention.

ZIFT, like IVF, is considered controversial by many scientists and laymen alike, because it makes PGD (Pre-implantation Genetic Diagnosis) possible, allowing parents to select the genetic makeup of their child before it is ever even implanted. Despite warnings about the implications of PGD (i.e. GATTACA), it is still commonly practiced alongside ZIFT and IVF.