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Bacteria resistance to antibiotics Featured science projectScience project video


This science fair project aims to find out how the frequent use of antibiotics affects bacteria resistance. This experiment is carried out using the antibiotic ampicillin and the bacteria, Escherichia Coli (E. Coli).


Repeated use of antibiotics causes bacteria to develop resistance which in turn, causes the antibiotic to become less effective in eliminating the bacteria.

Scientific Terms

Antibiotics, bacteria, resistant, microorganisms, evolving, genes, DNA


Bacterial resistance

Bacteria and other microorganisms exist all around us. Most of them are harmless to us. Some assist us in digesting our food while others make us sick. The discovery of antibiotics, other antimicrobial agents and immunization have tremendously reduced the proliferation of diseases caused by bacterial infection. However, the excessive use of antibiotics has resulted in bacteria resistance, where the bacteria develops an immunity towards the antibiotic and renders the antibiotic no longer effective.This may lead to the growth and multiplication of a new population of resistant bacteria. This may also lead to a longer recovery time for patients who are suffering from the infection. In addition, stronger and more expensive antibiotics with harmful side effects may have to be used on the patient.  

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Complexity level:
Project cost ($):
Time required:
1 day for preparation, 20 days for this science project experiment
Material availability:
Access to laboratory equipment (eg. petri dishes)
Safety concerns:

Always follow laboratory safety guidelines and always practice sterile technique when handling microbes. Never have any food or drink at your workstation and always thoroughly wash your hands with disinfectant soap or alcohol before leaving your workstation. Always dispose of used material in a biohazard bag. If none are available, the bacteria should be destroyed with bleach before being disposed of.