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Project title Manipulation of PGE(2) Levels with Various Cytokines of Thyroid Associated Ophthalmopathy
Difficulty Level High school
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Graves# Disease is a form of hyperthyroidism often accompanied by Thyroid Associated Ophthalmopathy (TAO), an autoimmune-mediated inflammation of the extraocular connective tissue. Despite numerous studies to locate the specific factors that regulate the swelling and produce an effective cure, neither of these goals has been achieved. Recently, scientists discovered that Prostaglandin E(2) (PGE(2)) is present in significantly increased levels in the orbital tissues of patients with TAO, and must be an important factor in the inflammatory response around the eyes. The primary goal of this research project was to determine the mechanisms that lie behind the up-regulation of PGE(2) in patients with TAO and establish correlations among Th1 and Th2 cytokines, growth factors, and PGE(2). 
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