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Virology Science Fair Project

The Effects of Influenza A Virus

Hard
The Effects of Influenza A Virus | Science Fair Projects | STEM Projects
In this project, we will explore the effects of the Influenza A Virus on the colonization of the nasopharynx and otitis media in the chinchilla model. We will investigate how the virus affects the adherence, the kinetics of colonization, and invasion of the middle ear by isogenic opaque and transparent variants of S. pneumoniae type 6A.

Hypothesis

The hypothesis is that the Influenza A Virus will promote significant colonization of the nasopharynx by S. pneumoniae and development of otitis media.

Method & Materials

You will use 48 healthy chinchillas and inoculate them intranasally with either the Influenza A Virus or diluent only. Then, 7 days later, you will inoculate them with either the opaque or transparent variant of S. pneumoniae type 6A.
You will need 48 healthy chinchillas, Influenza A Virus, diluent, and S. pneumoniae type 6A opaque and transparent variants.

Results

The results of this project indicate that the effects of the Influenza A Virus on the pathogenesis of S. pneumoniae-induced otitis media vary depending on the opacity phenotype of the S. pneumoniae inoculum. This observation stands out as it suggests that the virus may have different effects on different variants of the bacteria.

Why do this project?

This science project is interesting and unique because it explores the effects of the Influenza A Virus on the colonization of the nasopharynx and otitis media in the chinchilla model.

Also Consider

Experiment variations to consider include testing different viruses, such as adenovirus or respiratory syncytial virus, and different bacterial variants.

Full project details

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