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Allergies Science Fair Project

Investigating Cow's Milk Allergy

Hard
Investigating Cow's Milk Allergy | Science Fair Projects | STEM Projects
Are you curious about why some people are allergic to cow's milk? In this project, you'll explore the immunological mechanisms behind cow's milk sensitivity. By using flow cytometry, researchers examined the immune response of proinflammatory and regulatory lymphocytes from children with or without food allergies before and after challenge with cow's milk protein.

Hypothesis

The hypothesis is that the reduced production of regulatory cells might result in failure to establish immune tolerance within the intestine, allowing any potentially food-reactive lymphocyte to respond unchecked.

Method & Materials

You will use the technique of flow cytometry to examine the immune response of proinflammatory and regulatory lymphocytes from children with or without food allergies before and after challenge with cow's milk protein.
You will need flow cytometry, immunohistochemistry, and in situ hybridization.

Results

The results indicated that the major difference in children with food allergy was the deficiency of a regulatory lymphocyte population, rather than the excess of proinflammatory cells. This regulatory population, called TH3 cells, produce a cytokine (TGF-beta) which inhibits the activation of all other cells in the locality.

Why do this project?

This science project is interesting and unique because it examines the immunological mechanisms behind cow's milk sensitivity, which is a common food allergy in children.

Also Consider

Experiment variations to consider include examining the immune response of proinflammatory and regulatory lymphocytes from adults with or without food allergies before and after challenge with cow's milk protein, or examining the immune response of proinflammatory and regulatory lymphocytes from children with or without food allergies before and after challenge with other food proteins.

Full project details

You can find additional information and details for this science fair project here. Have fun exploring!
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