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1000 Science Fair Projects with Complete Instructions

Molecular Biology is the study of the tiny building blocks of life, like DNA and proteins, that make up cells. By studying molecular biology, we can understand how cells work, and even find ways to cure diseases!

Eureka Crateengineering & invention kits for ages 12+ — monthly projects that build real-world skills. (Affiliate link)

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Egg Weight Changes in Salt Water
Molecular Biology Science Fair Project
Easy
Weigh three eggs before and after soaking them in plain water and two salt solutions to see osmosis change their mass overnight.
Osmosis in Eggs Without Shells
Molecular Biology Science Fair Project
Medium
Soak shell-free eggs in three different solutions and watch osmosis shrink or swell each one.
Onion DNA Extraction with Household Items
Molecular Biology Science Fair Project
Medium
Crack open onion cells with detergent and meat tenderizer. Watch white strands of DNA float up in ice-cold ethanol.
pGLO Plasmid Bacterial Transformation
Molecular Biology Science Fair Project
Hard
Introduce the pGLO plasmid into E. coli through heat shock and watch transformed colonies glow under a UV lamp.
Nicotine and Colon Cancer Cell Growth
Molecular Biology Science Fair Project
Hard
Expose colon cancer cells to three nicotine concentrations and use a colorimetric assay to see which ones multiply.
Peptide Stability in Helices and Strands
Molecular Biology Science Fair Project
Hard
Build model peptides on a computer in three shapes and compare their energies to find out why nature prefers helices over flat chains.
Baculovirus Detection with a Quartz Biosensor
Molecular Biology Science Fair Project
Hard
Coat a vibrating quartz crystal with virus-catching antibodies and measure frequency changes to detect baculovirus particles.
Cytokines and PGE2 in Thyroid Eye Disease
Molecular Biology Science Fair Project
Hard
Culture three types of fibroblasts and treat them with cytokines to discover which immune signals drive PGE2 levels in thyroid eye disease.
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